TAM-related publications

   Huang et al., Microglia use TAM receptors to detect and engulf amyloid beta plaques. 
   Nat Immunol 2021 May;22(5):586-594 doi: 10.1038/s41590-021-00913-5. Epub 2021 Apr 15.

 

 

 

 
 
 
 

 

        

   Nicolás-Ávila et al., A network of macrophages supports mitochondrial homeostasis in the heart. 
   Cell 2020 Oct 1;183(1):94-109.e23. doi: 10.1016/j.cell.2020.08.031. Epub 2020 Sep 15.

 

 

                     

 

 

 

 

 

 

   Zagórska et al.,  Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer
   Life Sci Alliance 2020 Jun 22;3(8):3202000694. doi: 10.26508/Isa.202000694. Print 2020 Aug.

 

 

 

 

 

     Lemke et al., Blood clots and TAM receptor signalling in COVID-19 pathogenesis.
     Nat Rev Immunol 2020 Jun 2:1-2. doi: 10.1038/s41577-020-0354-x. Online ahead of print.

    

 

 

 

     Lemke, How macrophages deal with death.
    Nat Rev Immunol 2019 Sep;19(9):539-549. doi: 10.1038/s41577-019-0167-y.

     

 

 

 

 

 

 

     McShane L et al., TAM receptors in cardiovascular disease.
    Cardiovasc Res 2019 Jul 1;115(8):1286-1295. doi: 10.1093/cvr/cvz100.
     

 

 

 

     Lemke, Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.
    Trends Biochem Sci 2017 Sep;42(9):738-748. doi: 10.1016/j.tibs.2017.06.004. Epub 2017 Jul 19.
     

 

 

 

     Kurowska-Stolarska et al., MicroRNA-34a dependent regulation of AXL controls 
    
the activation of dendritic cells in inflammatory arthritis.
    
Nat Commun 2017 Jun 22;8:15877. doi: 10.1038/ncomms15877.

 

 
 
 

     Tufail et al., Phosphatidylserine Exposure Controls Viral Innate Immune
     Responses by Microglia.

     Neuron doi: 10.1016/j.neuron.2016.12.021 (2017)

 

 

 

     Fourgeaud et al., TAM receptors regulate multiple features of microglial physiology.
     Nature
doi: 10.1038/nature17630 (2016)

 

 

 

   Miner et al., The TAM receptor Mertk protects against neuorinvasive viral
   infection by maintaining blood-brain barrier integrity.
  
Nature Medicine doi: 10.1038/nm.3974 (2015)

 

 

 

  Lew et al., Differential TAM receptor-ligand-phospholipid interactions 
  delimit differential TAM bioactivities. Elife 3. doi: 10.7554/eLife.03385 (2014).

 

 

 

   Zagórska et al., Diversification of TAM receptor tyrosine kinase function.
   Nat Immunol. 15, 920-928 (2014).

 

 

 

 

 

   Lemke, Biology of the TAM Receptors
   Cold Spring Harb Perspect Biol.  5(11):a009076 (2013).

 

 

 


 

 

   Bhattacharyya et al., Enveloped Viruses Disable Innate Immune Responses in
   Dendritic Cells by Direct Activation of TAM Receptors
.
   Cell Host & Microbe 14, 136-147 (2013).

 

 

 

 

    Carrera Silva et al., T Cell-derived Protein S engages TAM receptor signaling in
   dendritic cells to control the magnitude of the immune response.
   
Immunity 39, 160-170 (2013).




 

 


    Burstyn-Cohen et al., Genetic dissection of TAM receptor-ligand interaction in
    retinal pigment epithelial cell phagocytosis.

    Neuron 76, 1123–1132 (2012).

 

 

 

 

    Meertens et al., The TIM and TAM families of phosphatidylserine receptors mediate
    dengue virus entry.
   
Cell Host and Microbe 12, 544-557 (2012).

 

 

 

 

    Bauer et al., Identification of Axl as a downstream effector of TGF-β1 during
    Langerhans cell differentiation and epidermal homeostasis.
   
Journal of Experimental Medicine 209, 2033-2047 (2012).

 

 

 

   Burstyn-Cohen et al., Lack of Protein S in mice causes embryonic
   lethal coagulopathy and vascular dysgenesis
.
   Journal of Clinical Investigation 119, 2942-2953 (2009).

 

 

 

 

   Lemke and Rothlin, Immunobiology of the TAM receptors.
   Nature Reviews Immunology 8, 327-336 (2008).

 

 

 

 

 

   Rothlin et al., TAM Receptors Are Pleiotropic Inhibitors of
   the Innate Immune Response.

   Cell 131, 1124–1136 (2007).

 

 

 

    Lu and Lemke, Homeostatic regulation of the immune system
    by receptor tyrosine kinases of the Tyro3 family.
    Science 293, 306311 (2001)

 

 


 

    Lu et al., Tyro-3 family receptors are essential regulators of
    mammalian spermatogenesis.
    Nature 398, 723-727 (1999).

 

 

 

 

   Stitt et al., The anticoagulation factor Protein S
   and its relative, Gas6, are Ligands for the
   Tyro 3/Axl family of Receptor Tyrosine Kinases.

   Cell 80, 661-671 (1995).

 


 

 

   Lai and Lemke, An extended family of protein-tyrosine kinase
   genes differentially expressed in the vertebrate nervous system.

   Neuron 6, 691-704 (1991).